Cardiovascular, Renal and Metabolism
Attacking a cluster
Metabolic diseases affect close to one billion people worldwide. Only four years old, the team is combining unparalleled clinical expertise with basic research and a renowned protein engineering technology platform. Our drug discovery teams are poised to deliver innovative therapies for cardiometabolic diseases and are already moving to the clinic.
Addressing the challenge of diabetes includes looking at insulin-producing β-Cells. When they can’t do their job, blood-glucose levels go awry. Our focus includes identifying novel pathways and targets that regulate β-Cell growth and function, and insulin demand—with an eye toward reversing both Type 1 and Type 2 diabetes.
Bariatric surgery is the only known cure for Type 2 diabetes, but the adverse effects are problematic for patients. Our scientists have identified several gut hormones that produce a “bariatric surgery-like” effect. Today, we are testing molecules that replicate this impact, without the surgical morbidities.
Chronic Kidney Disease
Combining our chronic kidney disease (CKD) pathology expertise with our proficiencies in immune system targeting and biologics technologies is helping us to better understand the disease biology of CKD. That approach is giving us the ability to construct novel drugs that combine multiple pharmacologic activities in a single agent or target specific tissues and cell types. Our aim is to keep people from kidney dialysis.
Every six seconds a person dies from diabetes. Our investigations focus on enhancing the phenomenon of reverse cholesterol transport—which reduces atherosclerotic plaque disease and residual CVD risk—and stem cell therapies for cardiac regeneration. These innovative approaches offer the possibility for substantial therapeutic benefits.
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